Family Eye Care of Bolingbrook
310 S. Weber Rd
Bolingbrook, Illinois 60490
Mon: 10:00 AM – 8:00 PM
Tue: 2:00 PM – 8:00 PM
Wed: 10:00 AM – 8:00 PM
Thur: 10:00 AM – 8:00 PM
Fri: 9:00 AM – 5:00 PM
Sat: 8:00 AM – 1:00 PM
PurposeTo assess the effect of intermediate age-related macular degeneration (AMD) on foveal cone-contrast thresholds.
MethodsWe measured L-M and S-cone-contrast thresholds in subjects with intermediate AMD (n = 10) and age-matched control subjects (n = 10). Monocular, foveal 3-degree Gaussian blobs (600-millisecond raised cosine) were presented at 16 cone ratios throughout L-, M-, and S-cone space, and threshold contours were modeled with probability summation between two independent detection mechanisms. The role that preretinal absorption plays in aging was also evaluated by simulation with FG15 and neutral-density filters.
ResultsAging results in loss of neural sensitivity, not explained by lens changes. On average, intermediate AMD was associated with reduced sensitivity in both color and luminance channels (p
PurposeThe aim of this study was to understand people’s experience with age-related macular degeneration (AMD) in light of new treatment successes.
MethodsAn interpretive qualitative methodology was used to facilitate understanding of the experience of people with AMD. Rich in-depth data were collected using focus groups and individual interviews. Thematic analysis of the data occurred through the processes of line-by-line coding, aggregation, and theme development using the NVivo 10 software.
ResultsA total of 4 focus groups and 16 individual interviews were conducted with 34 people (median age = 81 years; range = 56 to 102 years; 19 females) with AMD. Four major themes arose from the narratives of the participants: cautious optimism, enduring, adaptation, and profound loss. Cautious optimism resonated for participants who had received successful treatment and stabilization of AMD. Enduring emerged as participants with exudative AMD described an ongoing need for invasive and frequent treatments (anti–vascular endothelial growth factor injections) that maintained their vision. Adaptation was evident in the narratives of all participants and was directly related to the physical and psychological limitations that were a consequence of visual disability. Profound loss encompassed both physical and emotional aspects of deteriorating vision and was most evident in patients for whom treatment had failed or had not been considered appropriate for their disease.
ConclusionsThe findings of this study shed new light on the influence of underlying pathology, disease trajectory, and success of new treatments on quality of life of people living with AMD. Optimism toward maintaining vision in the presence of exudative AMD was described by participants, moderated by ongoing caution and a need for endurance of frequent and often problematic intravitreal treatments. These findings add a deeper understanding of this complex and life-changing experience.
Acute Transient Myopia With Shallowing of the Anterior Chamber Induced by Sulfamethoxazole in a Patient With Pseudoxanthoma Elasticum
Purpose:To report a case of acute transient myopia with anterior chamber shallowing induced by sulfamethoxazole in a patient with pseudoxanthoma elasticum (PXE).
Design:Observational case report.
Methods:A case report of a 45-year-old woman who presented with bilateral acute myopia, anterior chamber shallowing, and intraocular hypertension induced by sulfamethoxazole and was found to have PXE. Initial and follow-up examination findings were reviewed.
Results:On first examination, bilateral myopic shift of 4.25 D, bilateral narrowed angles, and ocular hypertension (36 mm Hg right eye and 38 mm Hg left eye) were found. Pentacam images documented the anterior displacement of the iris-lens diaphragm. Undilated fundus examination disclosed bilateral angioid streaks radiating from the papilla. Several redundant skin folds on the neck and axillae were found on external examination. With sulfamethoxazole discontinuation and administration of topical intraocular pressure–lowering drops, there was complete clinical resolution within 1 week. The diagnosis of PXE was confirmed by biopsy of the skin lesions.
Conclusions:Acute myopia with angle narrowing is an extremely rare sulfamethoxazole side effect, and its relationship, if any, with PXE is unknown. As far as we know, this is the first reported case of PXE presenting with bilateral angle narrowing induced by sulfamethoxazole.